Natural component of apple peels found to prevent muscle weakening
Looking for an effective way to prevent muscle wasting that accompanies aging and disease, the researchers have found a natural compound that is very promising.
Image via CrunchBase
The results published in the June issue of Cell Metabolism (a publication of Cell Press), a natural component of apple peels called ursolic identify as promising treatment for the condition newnutritional widespread and debilitating affects almost everyone at one time or another time
“Muscle wasting is a frequent companion of illness and aging,” said researcher from the University of Iowa, Iowa City. “It prolongs hospitalization, prevents delays in recovery and in some cases people go home. Was not well understood and there is no medicine for it.”
The research team for the first time saw what happened with gene activity in the muscles under conditions that promote the weakening. These studies revealed 63 genes in response to fasting in humans and mice and other 29th expression in the muscles of the two people who are fasting and those who change with spinal cord injuries A comparison of the gene expression signatures for signatures treated cells with more than 1300 small bioactive molecules, it led to ursolic as a compound capable of counteracting the effects of the atrophy.
“Ursolic acid is an interesting natural compound,” they said. “It’s part of the normal diet as a component of apple peels. Always say that an apple a day keeps the doctor away …”
Then the researchers gave subjects ursolic fasting laboratory. These experiments showed that ursolic could weaken against muscle, protect predicted. If ursolic for feeding normal subjects over a period of weeks was added grew their muscles. These effects can be on insulin signaling in muscle and improve the corrections in the gene signatures associated with atrophy can be traced.
The subjects received ursolic was also leaner and had lower blood levels of glucose, cholesterol and triglycerides. These findings suggest that ursolic acid may be responsible for some of the overall benefits of healthy eating.
“We know that if you eat a balanced diet like mom told us to eat you get this material”, the researchers said, “people who eat junk food do not understand.”
It is unclear whether the findings translate to patients